Regulation of neuroinflammatory response

Across TCGA cell cohorts, RNA activity of the Regulation of neuroinflammatory response pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NR1D1, RAB21, and SLC22A2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NR1D1 grouped by Regulation of neuroinflammatory response-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	NR1D1 →	-0.146	-0.870	<.001	.006	2	7
OVARY	RAB21 →	-0.320	-1.222	<.001	.001	3	5
SOFT_TISSUE	SLC22A2 →	+0.418	+1.605	.002	<.001	3	4
KIDNEY	MMP9 →	-0.254	-1.358	.006	<.001	2	5
KIDNEY	H2AZ2 →	-0.398	-1.283	.004	.005	3	4
OVARY	GRK7 →	-0.264	-1.542	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NR1D1 by Regulation of neuroinflammatory response activity — OESOPHAGUS

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