Regulation of neuroinflammatory response

Across TCGA cell cohorts, RNA activity of the Regulation of neuroinflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCS1L, UTP18, and SGTA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neuroinflammatory response activity versus BCS1L in PANCREAS (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	BCS1L →	+0.602	+0.942	.005	.007	3	5
BLOOD_Lymphoma	UTP18 →	+0.553	+0.238	.001	.002	3	5
SOFT_TISSUE	SGTA →	+0.597	+0.301	.001	.002	3	4
SOFT_TISSUE	GPAT4 →	+0.866	+0.286	<.001	.005	3	4
SOFT_TISSUE	PA2G4 →	+0.625	+0.284	.003	.005	3	4
OVARY	PCP2 →	-0.766	-1.383	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150077 vs BCS1L — PANCREAS

Explore this scatter interactively →