Neuroinflammatory response

Across TCGA patient cohorts, RNA activity of the Neuroinflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRA6, FGR, and ADGRE2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuroinflammatory response activity versus LILRA6 in COAD (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LILRA6 →	+0.731	+0.165	<.001	<.001	3	10
GBM	FGR →	+0.926	+0.254	<.001	.008	3	10
GBM	ADGRE2 →	+1.135	+0.420	<.001	<.001	3	9
GBM	PIK3R5 →	+1.143	+0.379	<.001	<.001	3	9
HNSC	CEACAM3 →	+0.634	+0.166	<.001	<.001	3	9
LSCC	ADGRG3 →	+0.908	+0.186	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150076 vs LILRA6 — COAD

Explore this scatter interactively →