Neuroinflammatory response

Across TCGA cell cohorts, RNA activity of the Neuroinflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPHP1, EIF3B, and SLC12A4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuroinflammatory response activity versus NPHP1 in BLOOD_Myeloma (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	NPHP1 →	+1.185	+1.795	<.001	<.001	3	4
URINARY_TRACT	EIF3B →	-0.491	-0.339	.002	.007	3	3
URINARY_TRACT	SLC12A4 →	+1.130	+0.311	.007	.009	3	3
URINARY_TRACT	CYP51A1 →	-1.206	-0.313	.008	.007	3	3
URINARY_TRACT	CYCS →	-0.707	-0.334	<.001	<.001	3	3
URINARY_TRACT	LCAT →	+1.626	+0.396	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150076 vs NPHP1 — BLOOD_Myeloma

Explore this scatter interactively →