Positive regulation of neuron projection arborization

Across TCGA patient cohorts, RNA activity of the Positive regulation of neuron projection arborization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DCK, GRIP1_S433, and PAWR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neuron projection arborization activity versus DCK in LSCC (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DCK →	-0.276	-0.048	.008	.006	3	6
PDAC	GRIP1_S433 →	+0.458	+0.036	.003	.001	3	6
PDAC	PAWR →	+0.314	+0.044	.002	.001	3	6
LSCC	TBXAS1 →	-0.451	-0.053	<.001	<.001	3	5
LSCC	BTK →	-0.397	-0.047	.003	.003	3	5
UCEC	SVIL →	+0.540	+0.053	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150012 vs DCK — LSCC

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