Positive regulation of neuron projection arborization

Across TCGA patient cohorts, RNA activity of the Positive regulation of neuron projection arborization pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRIP1, OSBPL9P4, and TRO, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neuron projection arborization activity versus GRIP1 in OV (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GRIP1 →	+0.979	+0.228	<.001	<.001	3	7
LSCC	OSBPL9P4 →	+0.661	+0.757	<.001	<.001	3	5
LSCC	TRO →	+0.885	+0.745	<.001	.004	3	4
UCEC	COL6A2 →	+0.986	+0.322	<.001	.006	3	4
UCEC	ADAM33 →	+0.948	+0.418	.001	.002	3	4
UCEC	TUB →	+1.159	+0.582	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150012 vs GRIP1 — OV

Explore this scatter interactively →