Positive regulation of neuron projection arborization

Across TCGA patient cohorts, RNA activity of the Positive regulation of neuron projection arborization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GRIP1_S43, GRIP1_S847, and GRIP1_S433, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neuron projection arborization activity versus GRIP1_S43 in LSCC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GRIP1_S43 →	+1.032	+0.587	<.001	<.001	3	7
OV	GRIP1_S847 →	+0.992	+0.351	<.001	<.001	3	5
LUAD	GRIP1_S433 →	+1.015	+0.816	.002	.003	3	4
OV	GRIP1_T972 →	+0.745	+0.309	<.001	.003	3	3
GBM	TUBA8 →	+0.657	+0.523	<.001	<.001	3	3
GBM	SORCS2 →	+0.473	+0.474	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150012 vs GRIP1_S43 — LSCC

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