Positive regulation of neuron projection arborization

Across TCGA cell cohorts, RNA activity of the Positive regulation of neuron projection arborization pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNX17, TRMT61B, and MAIP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNX17 grouped by Positive regulation of neuron projection arborization-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SNX17 →	+0.814	+1.756	.005	<.001	3	5
KIDNEY	TRMT61B →	+0.478	+0.957	.001	.005	3	5
CNS	MAIP1 →	+0.546	+1.121	<.001	<.001	3	5
OVARY	SFXN4 →	+0.629	+1.189	.006	<.001	3	5
CNS	SPRED2 →	+0.571	+0.848	.002	.006	3	5
LIVER	CFAP45 →	-0.993	-1.556	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNX17 by Positive regulation of neuron projection arborization activity — OESOPHAGUS

Explore this box plot interactively →