Positive regulation of neuron projection arborization

Across TCGA cell cohorts, RNA activity of the Positive regulation of neuron projection arborization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACADVL, CAMTA2, and KDM6B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neuron projection arborization activity versus ACADVL in BLOOD_Lymphoma (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ACADVL →	+0.799	+0.106	.003	.001	3	8
SOFT_TISSUE	CAMTA2 →	+0.933	+0.098	.002	.002	3	7
OVARY	KDM6B →	+0.852	+0.079	<.001	.007	3	7
SOFT_TISSUE	DLG4 →	+1.893	+0.118	<.001	<.001	3	7
SOFT_TISSUE	ADGRL1 →	+1.666	+0.078	.002	.009	3	7
OESOPHAGUS	ABCF3 →	+0.760	+0.127	<.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150012 vs ACADVL — BLOOD_Lymphoma

Explore this scatter interactively →