Regulation of neuron projection arborization

Across TCGA cell cohorts, RNA activity of the Regulation of neuron projection arborization pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HIVEP2, LAMA4, and RNF11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HIVEP2 grouped by Regulation of neuron projection arborization-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	HIVEP2 →	-1.605	-1.136	<.001	<.001	3	5
SOFT_TISSUE	LAMA4 →	-3.760	-1.321	.001	.002	3	4
OVARY	RNF11 →	-0.665	-1.215	.001	<.001	3	4
OVARY	SYNJ2 →	-1.195	-1.026	.005	.001	3	4
SKIN	RAB11FIP4 →	+1.350	+0.638	.004	.007	3	4
SKIN	MGAT2 →	-0.800	-0.675	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HIVEP2 by Regulation of neuron projection arborization activity — SOFT_TISSUE

Explore this box plot interactively →