Regulation of neuron projection arborization

Across TCGA cell cohorts, RNA activity of the Regulation of neuron projection arborization pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB26, GRB2, and FAM89B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB26 grouped by Regulation of neuron projection arborization-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	RAB26 →	+0.160	+0.152	.007	.002	3	4
CNS	GRB2 →	-0.254	-1.437	<.001	<.001	3	3
BLOOD_Leukemia	FAM89B →	-0.118	-1.349	.004	<.001	3	2
BLOOD_Leukemia	RFX3 →	-0.210	-1.378	.002	<.001	3	2
BLOOD_Leukemia	CDC45 →	+0.300	+1.321	.009	.002	3	2
KIDNEY	SUCLA2 →	+0.130	+0.177	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB26 by Regulation of neuron projection arborization activity — KIDNEY

Explore this box plot interactively →