Regulation of neuron projection arborization

Across TCGA cell cohorts, RNA activity of the Regulation of neuron projection arborization pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MACF1, POT1, and MAP2K6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neuron projection arborization activity versus MACF1 in LARGE_INTESTINE (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MACF1 →	+1.898	+1.311	.002	.001	3	3
LARGE_INTESTINE	POT1 →	+0.879	+1.311	<.001	.001	3	3
BLOOD_Leukemia	MAP2K6 →	+1.850	+0.947	.006	.008	3	3
CNS	HEXIM2 →	+0.700	+1.451	.007	<.001	3	3
STOMACH	FBLN1 →	+6.479	+1.544	.001	<.001	3	3
CNS	RETREG1 →	+2.760	+1.507	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150011 vs MACF1 — LARGE_INTESTINE

Explore this scatter interactively →