Regulation of spontaneous synaptic transmission

Across TCGA patient cohorts, RNA activity of the Regulation of spontaneous synaptic transmission pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC12A2, FNBP1L, and BDP1, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of spontaneous synaptic transmission activity versus SLC12A2 in CHOL (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	SLC12A2 →	+2.370	+0.121	<.001	<.001	3	28
THYM	FNBP1L →	+1.208	+0.055	<.001	<.001	3	22
PRAD	BDP1 →	+0.802	+0.078	<.001	<.001	3	21
ESCA	PDZD8 →	+1.080	+0.115	<.001	<.001	3	21
THYM	CCDC186 →	+0.866	+0.059	<.001	<.001	3	21
THYM	LTN1 →	+0.891	+0.061	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150003 vs SLC12A2 — CHOL

Explore this scatter interactively →