Regulation of spontaneous synaptic transmission

Across TCGA patient cohorts, RNA activity of the Regulation of spontaneous synaptic transmission pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC12A2, YBX3, and FHL3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of spontaneous synaptic transmission activity versus SLC12A2 in BRCA (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC12A2 →	+1.198	+0.789	<.001	.001	3	8
GBM	YBX3 →	-0.572	-0.130	.003	<.001	3	5
HNSC	FHL3 →	-0.528	-0.419	<.001	.003	3	4
UCEC	LINC01184 →	+0.506	+0.596	<.001	.008	2	5
COAD	CAV1 →	-0.904	-0.197	<.001	<.001	3	4
COAD	ROBO3 →	-0.442	-0.207	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150003 vs SLC12A2 — BRCA

Explore this scatter interactively →