Regulation of spontaneous synaptic transmission

Across TCGA cell cohorts, RNA activity of the Regulation of spontaneous synaptic transmission pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLIN3, CSF1, and GADD45B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLIN3 grouped by Regulation of spontaneous synaptic transmission-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PLIN3 →	-1.651	-0.884	<.001	.003	3	4
LUNG_NSCLC_LUSC	CSF1 →	-4.138	-0.987	<.001	.007	3	4
LUNG_NSCLC_LUSC	GADD45B →	-2.086	-0.920	<.001	.002	3	4
OVARY	ABCC3 →	-3.116	-1.476	.009	.002	3	4
OVARY	SEC31A →	-0.544	-0.926	.006	.004	3	4
OVARY	SLC4A4 →	-1.325	-1.348	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLIN3 by Regulation of spontaneous synaptic transmission activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →