Regulation of spontaneous synaptic transmission

Across TCGA cell cohorts, RNA activity of the Regulation of spontaneous synaptic transmission pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX28, PRIM1, and AHNAK2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of spontaneous synaptic transmission activity versus DDX28 in PANCREAS (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DDX28 →	-0.632	-0.186	.002	.002	3	6
URINARY_TRACT	PRIM1 →	-0.667	-0.118	.008	.001	3	6
BONE	AHNAK2 →	+3.051	+0.202	<.001	<.001	3	6
SOFT_TISSUE	TMSB10 →	+1.496	+0.176	.005	.004	3	5
BLOOD_Leukemia	ZFP1 →	-1.336	-0.266	.005	.002	3	5
OVARY	NUP93 →	-0.646	-0.126	.002	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150003 vs DDX28 — PANCREAS

Explore this scatter interactively →