Positive regulation of inflammasome-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of inflammasome-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAH1, AGO4, and XRN1, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of inflammasome-mediated signaling pathway activity versus DNAH1 in DLBC (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	DNAH1 →	+0.861	+0.064	<.001	<.001	3	28
DLBC	AGO4 →	+0.899	+0.066	<.001	<.001	3	28
DLBC	XRN1 →	+1.190	+0.068	<.001	<.001	3	28
SKCM	ZNF267 →	+0.951	+0.052	<.001	<.001	3	27
DLBC	SPATA13 →	+1.541	+0.064	<.001	<.001	3	27
TGCT	DDHD1 →	+0.810	+0.050	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0141087 vs DNAH1 — DLBC

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