Positive regulation of inflammasome-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of inflammasome-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA5, BCL7A, and EFCAB11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of inflammasome-mediated signaling pathway activity versus ANXA5 in BLOOD_Lymphoma (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ANXA5 →	-1.932	-0.836	.002	.002	2	6
BLOOD_Lymphoma	BCL7A →	+2.451	+0.568	.003	.004	3	4
CNS	EFCAB11 →	-0.625	-0.893	.003	<.001	3	4
CNS	RAB27A →	-1.051	-0.749	.004	.007	2	5
LUNG_NSCLC_LUSC	RPN2 →	-0.807	-1.005	<.001	.001	3	4
LUNG_NSCLC_LUAD	ACSF2 →	-1.391	-0.878	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0141087 vs ANXA5 — BLOOD_Lymphoma

Explore this scatter interactively →