Negative regulation of inflammasome-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of inflammasome-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFAF5, ESF1, and PCNX4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDUFAF5 grouped by Negative regulation of inflammasome-mediated signaling pathway-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NDUFAF5 →	-0.465	-0.376	.002	.006	3	4
PANCREAS	ESF1 →	-0.723	-0.692	.001	.004	2	4
LIVER	PCNX4 →	+1.523	+0.648	.001	<.001	3	3
LIVER	H4C11 →	-2.381	-0.684	.009	<.001	3	3
LIVER	DNAJA2 →	-0.481	-0.477	.001	.002	3	3
LUNG_NSCLC_LUSC	VTI1A →	-0.531	-1.833	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDUFAF5 by Negative regulation of inflammasome-mediated signaling pathway activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →