Negative regulation of inflammasome-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of inflammasome-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMP2, RPS17, and RPL32, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of inflammasome-mediated signaling pathway activity versus LAMP2 in LIVER (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	LAMP2 →	+2.387	+0.358	.008	<.001	2	7
BLOOD_Leukemia	RPS17 →	-0.504	-0.175	.002	.006	3	6
PANCREAS	RPL32 →	-0.797	-0.169	.003	.005	3	6
CNS	CZIB →	-0.480	-0.172	.001	.002	3	5
BLOOD_Leukemia	FMR1 →	+0.807	+0.177	<.001	<.001	3	5
SKIN	ZNF570 →	+0.987	+0.129	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0141086 vs LAMP2 — LIVER

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