Regulation of inflammasome-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of inflammasome-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBX8, BRSK2, and ZNRF2P1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of inflammasome-mediated signaling pathway activity versus CBX8 in HNSC (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CBX8 →	-0.560	-0.222	.001	.009	3	4
HNSC	BRSK2 →	-0.326	-0.199	.008	<.001	3	4
BRCA	ZNRF2P1 →	-0.819	-0.272	<.001	.001	3	4
OV	POLD2 →	-0.419	-0.187	<.001	<.001	3	3
OV	SERPING1 →	+0.764	+0.171	.003	.002	3	3
OV	TCIM →	+1.331	+0.228	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0141085 vs CBX8 — HNSC

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