Regulation of inflammasome-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of inflammasome-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZWINT, ZDHHC8, and PAPLN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZWINT grouped by Regulation of inflammasome-mediated signaling pathway-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZWINT →	+0.577	+0.273	.002	<.001	3	4
BLOOD_Myeloma	ZDHHC8 →	-0.995	-0.260	.006	.008	3	3
URINARY_TRACT	PAPLN →	-2.565	-0.381	.001	.001	3	3
BONE	F2R →	-1.978	-0.274	<.001	.006	3	3
BLOOD_Leukemia	IVNS1ABP →	+0.820	+0.236	<.001	<.001	3	2
BLOOD_Leukemia	DEK →	+0.870	+0.290	.008	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZWINT by Regulation of inflammasome-mediated signaling pathway activity — SOFT_TISSUE

Explore this box plot interactively →