Regulation of inflammasome-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of inflammasome-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAGA, LGMN, and ELOVL5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of inflammasome-mediated signaling pathway activity versus NAGA in BREAST (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NAGA →	-0.727	-0.184	.003	<.001	3	5
BLOOD_Leukemia	LGMN →	+2.446	+0.248	.001	<.001	3	5
OESOPHAGUS	ELOVL5 →	+2.344	+0.168	.001	.002	3	5
BLOOD_Leukemia	ZNF236 →	+0.469	+0.143	.004	.002	3	5
BONE	SIVA1 →	+0.894	+0.158	.007	.008	2	6
CNS	TXN2 →	-0.566	-0.205	.003	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0141085 vs NAGA — BREAST

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