Inflammasome-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Inflammasome-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNRF2P1, SYNGR1, and MMAB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inflammasome-mediated signaling pathway activity versus ZNRF2P1 in BRCA (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNRF2P1 →	-0.740	-0.234	<.001	<.001	3	5
BRCA	SYNGR1 →	-0.576	-0.218	.003	<.001	3	4
HNSC	MMAB →	-0.393	-0.150	.005	.006	3	4
GBM	GLB1L2 →	-0.857	-0.120	<.001	.006	3	4
BRCA	WDR90 →	-0.596	-0.133	.007	.009	2	5
BRCA	MELTF-AS1 →	-0.983	-0.255	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0141084 vs ZNRF2P1 — BRCA

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