Inflammasome-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Inflammasome-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEBPD, SYCE1L, and GRID2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CEBPD grouped by Inflammasome-mediated signaling pathway-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CEBPD →	-2.066	-1.138	<.001	<.001	3	5
PANCREAS	SYCE1L →	-1.107	-1.293	<.001	<.001	3	4
BLOOD_Myeloma	GRID2 →	-0.570	-1.051	.002	.004	3	3
BREAST	MEA1 →	-0.492	-0.673	.005	.006	3	3
KIDNEY	RNF8 →	+0.641	+1.136	.002	.001	3	3
KIDNEY	EYA4 →	-1.685	-1.602	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CEBPD by Inflammasome-mediated signaling pathway activity — OVARY

Explore this box plot interactively →