Inflammasome-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Inflammasome-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAPPC9, PYCARD, and NLRC5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inflammasome-mediated signaling pathway activity versus TRAPPC9 in BLOOD_Lymphoma (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TRAPPC9 →	+0.838	+1.125	<.001	<.001	3	4
KIDNEY	PYCARD →	+3.807	+1.971	.005	<.001	3	4
SOFT_TISSUE	NLRC5 →	-2.183	-1.352	.001	<.001	3	3
STOMACH	GAR1 →	-1.203	-2.118	.001	<.001	3	3
STOMACH	RAB27B →	-2.903	-2.167	.008	<.001	3	3
BONE	HSCB →	+0.909	+1.604	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0141084 vs TRAPPC9 — BLOOD_Lymphoma

Explore this scatter interactively →