Disruption of anatomical structure in another organism

Across TCGA cell cohorts, RNA activity of the Disruption of anatomical structure in another organism pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSH2, SMIM30, and SPG21, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MSH2 grouped by Disruption of anatomical structure in another organism-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MSH2 →	-0.470	-1.042	.002	.002	3	4
OVARY	SMIM30 →	-0.994	-0.629	.001	.009	3	4
SKIN	SPG21 →	-0.368	-0.607	.001	.005	3	3
KIDNEY	ARFGEF3 →	-1.475	-0.854	.002	.008	3	3
LARGE_INTESTINE	RIPK2 →	+0.584	+0.720	.008	.003	3	3
UPPER_AERODIGESTIVE_TRACT	SERP1 →	+0.797	+1.156	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MSH2 by Disruption of anatomical structure in another organism activity — SKIN

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