Disruption of anatomical structure in another organism

Across TCGA cell cohorts, RNA activity of the Disruption of anatomical structure in another organism pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF213, PEX7, and ZNF221, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Disruption of anatomical structure in another organism activity versus RNF213 in PANCREAS (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RNF213 →	-1.378	-0.267	<.001	<.001	3	5
BONE	PEX7 →	+0.857	+0.236	.004	.007	3	5
SOFT_TISSUE	ZNF221 →	+0.554	+0.281	.006	.001	3	4
PANCREAS	RANGRF →	+1.127	+0.227	.004	.009	3	4
PANCREAS	RPL13A →	+1.001	+0.258	.006	.005	2	5
PANCREAS	ABHD10 →	+0.605	+0.211	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0141060 vs RNF213 — PANCREAS

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