Multicellular organismal-level chemical homeostasis

Across TCGA cell cohorts, RNA activity of the Multicellular organismal-level chemical homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SELENOM, TMC6, and SLC30A4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SELENOM grouped by Multicellular organismal-level chemical homeostasis-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SELENOM →	-1.128	-0.229	.005	.003	2	6
OVARY	TMC6 →	+2.088	+1.203	<.001	<.001	3	5
LUNG_NSCLC_LUSC	SLC30A4 →	-1.053	-0.332	<.001	<.001	3	4
LUNG_NSCLC_LUAD	CBLC →	+1.951	+0.668	.002	.003	3	4
LIVER	PDXDC1 →	+1.218	+1.280	.002	.004	3	4
KIDNEY	MXRA7 →	-1.888	-1.066	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SELENOM by Multicellular organismal-level chemical homeostasis activity — BLOOD_Leukemia

Explore this box plot interactively →