Interferon-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interferon-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL10RA, BTN3A3, and ZNFX1, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interferon-mediated signaling pathway activity versus IL10RA in LAML (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	IL10RA →	+1.662	+0.053	<.001	<.001	3	34
UVM	BTN3A3 →	+1.760	+0.050	<.001	<.001	3	34
DLBC	ZNFX1 →	+1.161	+0.069	<.001	<.001	3	34
SKCM	FGL2 →	+1.947	+0.044	<.001	<.001	3	34
DLBC	WDFY4 →	+1.562	+0.047	.001	.003	3	34
LAML	HELZ2 →	+1.392	+0.058	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140888 vs IL10RA — LAML

Explore this scatter interactively →