Interferon-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interferon-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAT1, TRIM21, and GBP4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interferon-mediated signaling pathway activity versus STAT1 in BRCA (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	STAT1 →	+0.741	+0.044	<.001	<.001	3	10
GBM	TRIM21 →	+0.406	+0.071	<.001	<.001	3	10
BRCA	GBP4 →	+0.846	+0.040	<.001	<.001	3	10
BRCA	GBP5 →	+1.104	+0.035	<.001	<.001	3	10
HNSC	IFIT3 →	+0.941	+0.062	<.001	.005	3	10
BRCA	LCP2 →	+0.617	+0.038	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140888 vs STAT1 — BRCA

Explore this scatter interactively →