Interferon-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Interferon-mediated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALOX15P1, PCDHB16, and PVR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ALOX15P1 grouped by Interferon-mediated signaling pathway-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ALOX15P1 →	-0.270	-1.475	.008	.005	3	4
BLOOD_Lymphoma	PCDHB16 →	+0.456	+2.190	.004	<.001	3	3
PANCREAS	PVR →	-0.170	-1.465	.009	.003	3	3
STOMACH	HAPLN3 →	+0.205	+1.817	<.001	.003	3	3
KIDNEY	C19orf48 →	-0.282	-1.812	<.001	<.001	3	3
CNS	SDC1 →	+0.120	+0.268	.006	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ALOX15P1 by Interferon-mediated signaling pathway activity — PANCREAS

Explore this box plot interactively →