DNA repair-dependent chromatin remodeling

Across TCGA patient cohorts, RNA activity of the DNA repair-dependent chromatin remodeling pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HM13, SND1, and ALG5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA repair-dependent chromatin remodeling activity versus HM13 in UCEC (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HM13 →	-0.536	-0.081	.004	.002	3	6
GBM	SND1 →	-0.235	-0.032	.003	.007	3	6
PDAC	ALG5 →	-0.283	-0.022	<.001	<.001	3	6
GBM	RPL38 →	-0.266	-0.052	<.001	<.001	3	5
GBM	RPL5 →	-0.163	-0.033	.002	<.001	3	5
GBM	RPS7 →	-0.364	-0.045	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140861 vs HM13 — UCEC

Explore this scatter interactively →