DNA repair-dependent chromatin remodeling

Across TCGA patient cohorts, RNA activity of the DNA repair-dependent chromatin remodeling pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMELESS, HELLS, and TEDC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA repair-dependent chromatin remodeling activity versus TIMELESS in BRCA (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TIMELESS →	+0.476	+0.438	<.001	.002	3	4
LSCC	HELLS →	+0.623	+0.122	<.001	.001	3	4
BRCA	TEDC2 →	+0.648	+0.402	.001	<.001	3	4
HNSC	SPAG5 →	+0.655	+0.129	.008	.007	2	5
HNSC	LIG1 →	+0.596	+0.162	.001	.002	3	4
HNSC	TTK →	+0.550	+0.148	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140861 vs TIMELESS — BRCA

Explore this scatter interactively →