DNA repair-dependent chromatin remodeling

Across TCGA cell cohorts, RNA activity of the DNA repair-dependent chromatin remodeling pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD12, SHISAL1, and VEGFC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANKRD12 grouped by DNA repair-dependent chromatin remodeling-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ANKRD12 →	-0.774	-0.307	<.001	<.001	3	4
OVARY	SHISAL1 →	-0.781	-0.165	.002	.002	3	4
CNS	VEGFC →	-2.584	-0.407	<.001	.002	3	4
BLOOD_Lymphoma	KDM5C →	+0.874	+0.308	<.001	.001	3	4
BREAST	TELO2 →	+0.818	+0.238	.001	.001	3	4
CNS	CHN2 →	+2.043	+0.211	.006	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANKRD12 by DNA repair-dependent chromatin remodeling activity — CNS

Explore this box plot interactively →