DNA repair-dependent chromatin remodeling

Across TCGA cell cohorts, RNA activity of the DNA repair-dependent chromatin remodeling pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCTD7, ZBTB14, and PRKACB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA repair-dependent chromatin remodeling activity versus KCTD7 in SKIN (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KCTD7 →	+0.867	+0.501	.003	.006	3	5
LUNG_NSCLC_LUAD	ZBTB14 →	+0.283	+0.522	.007	.004	3	5
LARGE_INTESTINE	PRKACB →	+1.475	+0.792	<.001	.001	3	4
LARGE_INTESTINE	POM121 →	+0.659	+0.874	<.001	.001	3	4
LARGE_INTESTINE	MZT1 →	+0.502	+0.817	.009	.002	3	4
BREAST	RNF11 →	+0.625	+0.542	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140861 vs KCTD7 — SKIN

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