Constitutive heterochromatin formation

Across TCGA patient cohorts, RNA activity of the Constitutive heterochromatin formation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GINS2, CENPO, and CDCA2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Constitutive heterochromatin formation activity versus GINS2 in GBM (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GINS2 →	+0.952	+0.830	<.001	<.001	3	8
GBM	CENPO →	+0.520	+0.642	.001	.006	3	8
BRCA	CDCA2 →	+0.763	+0.373	<.001	<.001	3	8
BRCA	SUV39H1 →	+0.576	+0.610	<.001	<.001	3	7
BRCA	CENPI →	+0.835	+0.571	<.001	<.001	3	7
LSCC	TMEM97 →	+1.224	+1.643	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140719 vs GINS2 — GBM

Explore this scatter interactively →