Constitutive heterochromatin formation

Across TCGA cell cohorts, RNA activity of the Constitutive heterochromatin formation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOMO3, ZNF563, and TSEN34, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NOMO3 grouped by Constitutive heterochromatin formation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NOMO3 →	-1.243	-0.379	<.001	<.001	3	4
OVARY	ZNF563 →	-0.661	-0.526	.001	.006	3	4
LUNG_SCLC	TSEN34 →	+0.797	+0.227	.001	.007	3	3
LUNG_NSCLC_LUAD	NUDT6 →	-0.917	-0.495	<.001	.009	2	4
BLOOD_Leukemia	IL15RA →	-1.417	-0.303	.002	<.001	3	3
BLOOD_Leukemia	DNAJC30 →	+0.726	+0.297	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NOMO3 by Constitutive heterochromatin formation activity — SOFT_TISSUE

Explore this box plot interactively →