Constitutive heterochromatin formation

Across TCGA cell cohorts, RNA activity of the Constitutive heterochromatin formation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD63, TMEFF1, and GKAP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Constitutive heterochromatin formation activity versus CD63 in BLOOD_Lymphoma (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CD63 →	-1.575	-0.928	.001	.008	3	7
LUNG_SCLC	TMEFF1 →	+1.498	+0.570	<.001	.009	3	6
BONE	GKAP1 →	+1.830	+1.617	<.001	<.001	3	6
BONE	STRBP →	+2.055	+1.620	.004	<.001	3	6
LUNG_SCLC	ST6GAL1 →	+2.728	+0.775	<.001	.003	3	6
BLOOD_Leukemia	SKP2 →	+0.937	+0.748	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140719 vs CD63 — BLOOD_Lymphoma

Explore this scatter interactively →