Facultative heterochromatin formation

Across TCGA patient cohorts, RNA activity of the Facultative heterochromatin formation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGO1, FANCB, and GINS1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Facultative heterochromatin formation activity versus SGO1 in UCEC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SGO1 →	+0.714	+1.195	<.001	<.001	3	9
LUAD	FANCB →	+0.809	+0.603	<.001	<.001	3	9
LUAD	GINS1 →	+0.910	+0.362	<.001	<.001	3	8
BRCA	EZH2 →	+0.951	+1.404	<.001	<.001	3	8
UCEC	TIMELESS →	+0.863	+0.943	<.001	<.001	3	8
BRCA	HROB →	+0.805	+1.414	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140718 vs SGO1 — UCEC

Explore this scatter interactively →