Facultative heterochromatin formation

Across TCGA cell cohorts, RNA activity of the Facultative heterochromatin formation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA5, NKX3-1, and GLRX, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITGA5 grouped by Facultative heterochromatin formation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ITGA5 →	-3.186	-0.368	.001	.009	3	6
BREAST	NKX3-1 →	-1.134	-0.667	<.001	.005	3	6
CNS	GLRX →	-1.348	-0.819	<.001	.003	3	6
OVARY	GPR176 →	-2.303	-1.018	.006	.008	3	6
BREAST	CTNNAL1 →	-1.417	-0.799	.005	.005	3	6
BREAST	ANKRD46 →	+0.617	+0.683	.004	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITGA5 by Facultative heterochromatin formation activity — STOMACH

Explore this box plot interactively →