Facultative heterochromatin formation

Across TCGA cell cohorts, RNA activity of the Facultative heterochromatin formation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF600, SLC25A6, and POLR2E, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Facultative heterochromatin formation activity versus ZNF600 in OVARY (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ZNF600 →	-1.173	-0.536	<.001	.006	3	4
SKIN	SLC25A6 →	-0.757	-0.507	.002	.008	3	4
SKIN	POLR2E →	-0.494	-0.564	.004	.003	3	4
KIDNEY	LENG8 →	-1.583	-0.306	.002	.004	3	3
STOMACH	TMEM150A →	-1.074	-0.382	.005	.004	3	3
STOMACH	ORMDL3 →	-1.262	-0.367	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140718 vs ZNF600 — OVARY

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