Transcription elongation-coupled chromatin remodeling

Across TCGA patient cohorts, RNA activity of the Transcription elongation-coupled chromatin remodeling pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAT1, WAS, and DEF6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription elongation-coupled chromatin remodeling activity versus STAT1 in LSCC (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STAT1 →	+0.494	+0.055	<.001	<.001	3	7
BRCA	WAS →	+0.388	+0.030	<.001	.004	3	7
UCEC	DEF6 →	+0.369	+0.066	<.001	.007	3	7
UCEC	DOCK2 →	+0.464	+0.081	.001	.001	3	7
CCRCC	LPXN →	+0.471	+0.033	<.001	<.001	3	7
BRCA	MYO1G →	+0.432	+0.033	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140673 vs STAT1 — LSCC

Explore this scatter interactively →