Transcription elongation-coupled chromatin remodeling

Across TCGA patient cohorts, RNA activity of the Transcription elongation-coupled chromatin remodeling pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEXN, MCM4, and JDP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription elongation-coupled chromatin remodeling activity versus NEXN in PDAC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	NEXN →	-0.534	-0.399	<.001	.005	3	6
COAD	MCM4 →	+0.647	+0.656	<.001	.002	3	6
UCEC	JDP2 →	-0.649	-0.364	.003	.004	3	5
OV	C19orf48 →	+0.563	+0.695	.007	.006	3	5
OV	SLC25A5 →	+0.480	+0.564	.001	.001	3	5
LUAD	ADRA1A →	-0.422	-0.146	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140673 vs NEXN — PDAC

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