Transcription elongation-coupled chromatin remodeling

Across TCGA cell cohorts, RNA activity of the Transcription elongation-coupled chromatin remodeling pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF6L, AARS1, and HMGCL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TAF6L grouped by Transcription elongation-coupled chromatin remodeling-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TAF6L →	-1.284	-0.185	.006	.008	3	4
KIDNEY	AARS1 →	-0.848	-0.219	.005	.004	2	5
BLOOD_Lymphoma	HMGCL →	-1.006	-0.249	.003	.001	2	5
LUNG_SCLC	TMEM42 →	-0.997	-0.172	.001	.002	3	4
URINARY_TRACT	SPATA21 →	-0.180	-0.157	.002	.006	3	4
STOMACH	MORN1 →	-0.945	-0.212	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TAF6L by Transcription elongation-coupled chromatin remodeling activity — BLOOD_Myeloma

Explore this box plot interactively →