Transcription elongation-coupled chromatin remodeling

Across TCGA cell cohorts, RNA activity of the Transcription elongation-coupled chromatin remodeling pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BAZ1B, CARMIL2, and NUP188, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription elongation-coupled chromatin remodeling activity versus BAZ1B in BLOOD_Leukemia (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BAZ1B →	+0.887	+0.209	<.001	.002	3	7
KIDNEY	CARMIL2 →	+0.870	+1.701	.002	.008	3	5
KIDNEY	NUP188 →	+1.525	+1.215	<.001	.009	3	5
BONE	FOXJ3 →	+0.852	+0.314	<.001	.001	3	5
BLOOD_Leukemia	CELF1 →	+0.490	+0.241	<.001	.001	3	5
BLOOD_Leukemia	TRRAP →	+1.060	+0.268	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140673 vs BAZ1B — BLOOD_Leukemia

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