Transcription elongation-coupled chromatin remodeling

Across TCGA cell cohorts, RNA activity of the Transcription elongation-coupled chromatin remodeling pathway is significantly associated with the protein abundance of multiple proteins, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRSF1, HNRNPU, and SRSF3, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription elongation-coupled chromatin remodeling activity versus SRSF1 in LARGE_INTESTINE (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SRSF1 →	+0.365	+0.620	.003	.008	3	12
KIDNEY	HNRNPU →	+0.504	+1.536	.001	.001	2	13
BLOOD_Leukemia	SRSF3 →	+0.413	+0.236	<.001	.001	3	12
CNS	SRSF7 →	+0.597	+1.176	<.001	<.001	3	10
LUNG_NSCLC_LUAD	SNRPA1 →	+0.465	+0.641	.003	.007	3	10
SKIN	DHX9 →	+0.250	+0.565	.009	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140673 vs SRSF1 — LARGE_INTESTINE

Explore this scatter interactively →