Positive regulation of pyroptosis

Across TCGA patient cohorts, RNA activity of the Positive regulation of pyroptosis pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF1, IL2RB, and GBP5, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of pyroptosis activity versus IRF1 in COAD (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IRF1 →	+0.839	+0.173	<.001	<.001	3	10
UCEC	IL2RB →	+1.108	+0.242	<.001	<.001	3	9
CCRCC	GBP5 →	+1.393	+0.181	<.001	<.001	3	9
UCEC	PRF1 →	+1.327	+0.221	<.001	<.001	3	9
BRCA	TRAC →	+1.290	+0.157	<.001	<.001	3	9
COAD	GBP1 →	+1.162	+0.203	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140639 vs IRF1 — COAD

Explore this scatter interactively →