Positive regulation of pyroptosis

Across TCGA cell cohorts, RNA activity of the Positive regulation of pyroptosis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAYSD1, USP7, and DEPP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SAYSD1 grouped by Positive regulation of pyroptosis-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SAYSD1 →	+1.007	+1.701	<.001	.003	3	4
BREAST	USP7 →	+0.661	+0.965	.001	<.001	3	4
BLOOD_Myeloma	DEPP1 →	+2.979	+1.502	.004	.007	3	3
BLOOD_Myeloma	ZNF682 →	-2.420	-2.221	.001	<.001	3	3
LUNG_NSCLC_LUSC	IGSF3 →	+2.173	+1.454	.002	<.001	3	3
LUNG_NSCLC_LUSC	VWA3B →	-0.126	-1.106	.009	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SAYSD1 by Positive regulation of pyroptosis activity — BONE

Explore this box plot interactively →