Positive regulation of pyroptosis

Across TCGA cell cohorts, RNA activity of the Positive regulation of pyroptosis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COX6B1, SLC22A4, and BEAN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of pyroptosis activity versus COX6B1 in BREAST (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	COX6B1 →	-0.678	-0.974	.002	.006	3	4
BREAST	SLC22A4 →	-1.090	-1.137	.001	<.001	3	4
BLOOD_Lymphoma	BEAN1 →	-0.297	-0.997	.003	.007	3	4
KIDNEY	CIAO2B →	-0.338	-0.199	.006	.006	3	3
BREAST	INTS9 →	+0.611	+0.915	.004	.001	3	3
BREAST	ZNF787 →	-0.699	-1.162	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140639 vs COX6B1 — BREAST

Explore this scatter interactively →